Liraglutide

Pronunciation: LIR-a-GLOO-tide
Generic Name: Liraglutide
Brand Name: Victoza

Liraglutide has been shown to cause thyroid cancer in rats and mice. The risk increased with high doses and prolonged use. It is not known if Liraglutide may cause thyroid cancer in humans.

Do not use Liraglutide if you or a family member have had medullary thyroid carcinoma (MTC; a certain type of thyroid cancer), or if you have multiple endocrine neoplasia syndrome type 2 (MEN 2; another type of cancer). Lab tests, including calcitonin levels or thyroid ultrasound, may be performed while you are using Liraglutide. It is not known if having these tests decreases the risk of thyroid cancer. Discuss any questions or concerns with your doctor.

Contact your doctor immediately if you have a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.

Liraglutide is used for:

Treating type 2 diabetes. It is used along with diet and exercise.

Liraglutide is a glucagon-like peptide (GLP)-1 receptor agonist. It works by increasing the amount of insulin that your body produces. It also helps to decrease the amount of sugar that the liver produces and the intestines absorb.

Do NOT use Liraglutide if:

• you are allergic to any ingredient in Liraglutide


• you or a family member has a history of MTC


• you have MEN 2


• you have type 1 diabetes


• you have diabetic ketoacidosis (high blood acid levels)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Liraglutide:

Some medical conditions may interact with Liraglutide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney or liver problems, thyroid cancer, pancreas inflammation (pancreatitis), or stones in your gallbladder (gallstones)


• if you have high blood triglyceride levels, trouble digesting food, or slowed emptying of the stomach


• if you have a history of alcohol abuse


• if you have never taken another medicine for type 2 diabetes


• if you are using insulin

Some MEDICINES MAY INTERACT with Liraglutide. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Oral diabetes medicines (eg, glyburide) because the risk of low blood sugar may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Liraglutide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Liraglutide:

Use Liraglutide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Liraglutide comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Liraglutide refilled.


• Use Liraglutide with or without food.


• A health care provider will teach you how to use Liraglutide. Be sure you understand how to use Liraglutide. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Use the proper technique taught to you by your health care provider. Inject deep under the skin, in the stomach area (abdomen), upper leg (thigh), or upper arm, as directed by your doctor. Do NOT inject Liraglutide into a vein or muscle.


• Do not use Liraglutide if it contains particles, is cloudy or discolored, or if the pen is cracked or damaged.


• Before the first use of a new pen, follow the "First Time Use for Each New Pen" instructions in the Patient Instructions for Use. You only need to do this 1 time with each new pen. Also do this if you drop your pen. Do NOT do this before each injection.


• Remove the needle after each injection and dispose of it properly. Do not store Liraglutide with the needle attached. Doing so may increase the risk that Liraglutide will leak or that germs will enter your medicine.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• Use Liraglutide on a regular schedule to get the most benefit from it.


• If you miss a dose of Liraglutide, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Liraglutide.

Important safety information:

• Follow the diet and exercise program given to you by your health care provider.


• Do NOT take more than the recommended dose without checking with your doctor.


• Tell your doctor or dentist that you take Liraglutide before you receive any medical or dental care, emergency care, or surgery.


• Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Liraglutide exactly as prescribed, tell your doctor.


• Liraglutide may increase the risk of low blood sugar when used with other medicines that can cause low blood sugar (eg, sulfonylureas). Low blood sugar may also be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. Tell your doctor right away if this happens.


• It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar, like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.


• Fever, infection, injury, or surgery may increase your risk for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away.


• Liraglutide may change the way that medicines taken by mouth are absorbed into your body. Be sure your doctor knows about all the medicines you take. Discuss any questions or concerns with your doctor.


• If diarrhea, nausea, or vomiting occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions. Dehydration may lead to new or worsening kidney problems.


• Lab tests, including calcitonin levels, thyroid ultrasound, fasting blood glucose, or hemoglobin A1c, may be performed while you use Liraglutide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Liraglutide should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Liraglutide while you are pregnant. It is not known if Liraglutide is found in breast milk. Do not breast-feed while using Liraglutide.

Possible side effects of Liraglutide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; decreased appetite; diarrhea; dizziness; headache; mild back pain; nausea; pain, swelling, or redness at the injection site; sinus inflammation; sore throat; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; difficult or painful urination; severe stomach or back pain (with or without vomiting); symptoms of thyroid cancer (eg, lump or swelling in the neck, trouble swallowing, shortness of breath, persistent hoarseness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Liraglutide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe nausea and vomiting.

Proper storage of Liraglutide:

Store new (unopened) pens in a refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze or store right next to the cooling element in the refrigerator.

Store used (open) pens either in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C), or at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Throw away used pens after 30 days, even if they still contain medicine.

Store Liraglutide away from excessive heat and sunlight. Do not use Liraglutide if it has been frozen or overheated (above 86 degrees F). Keep the pen dry. Do not store Liraglutide with a needle attached to the pen. Do not use Liraglutide past the expiration date on the carton. Keep Liraglutide out of the reach of children and away from pets.

General information:

• If you have any questions about Liraglutide, please talk with your doctor, pharmacist, or other health care provider.


• Liraglutide is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Liraglutide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Liraglutide resources

• Liraglutide Side Effects (in more detail)
• Liraglutide Use in Pregnancy & Breastfeeding
• Liraglutide Drug Interactions
• Liraglutide Support Group
• 142 Reviews for Liraglutide - Add your own review/rating

• Liraglutide Professional Patient Advice (Wolters Kluwer)


• liraglutide Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information


• Victoza Prescribing Information (FDA)


• Victoza Consumer Overview

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